CD117和Ki67在卵巢上皮性癌组织中的表达及临床意义

EXPRESSION AND CLINICAL SIGNIFICANCE OF CD117 AND Ki67 IN EPITHELIAL OVARIAN CANCER

目的探讨CD117及Ki67在卵巢上皮性癌组织中的表达及其与临床病理特征间的关系。方法采用免疫组织化学SP法测定60例卵巢上皮性癌标本及20例卵巢正常组织中CD117及Ki67的表达,结合临床病理资料进行分析。结果卵巢上皮性癌标本中CD117阳性表达率65.0%,明显高于正常卵巢组织的10.0%(P<0.05);Ki67表达率阳性表达率76.7%,明显高于正常卵巢组织的15.0%,差异有统计学意义(P<0.05)。高级别卵巢癌组CD117及Ki67的阳性表达率明显高于低级别组(P<0.05);而且CD117、Ki67阳性表达率随国际妇产科联盟(International Federation of Gynecology and Obstetrics,FIGO)分期进展及残余肿瘤大小而升高(P<0.05)。CD117与Ki67的表达无相关性。结论 CD117和Ki67的表达与卵巢癌的发生发展有密切关系,CD117和Ki67的检测可用于判断卵巢上皮性肿瘤的恶性程度及其预后。

Objective To investigate the expression of CDll7 and Ki67 in epithelial ovarian cancer and the relationship between their expression and clinicopathologic characteristics. Methods CD117 and Ki67 were detected by immunohistochemistry （SP method） in 60 samples of epithelial ovarian carcinoma,20 samples of normal ovarian tissues. Results The positive expression rate of CDll7 in ovarian epithelial carcinomas accounted for 65.0% , which was statistically higher than that of normal ovarian 10. 0% （P 〈 0. 05 ）. The positive expression rate of Ki67 in ovarian epithelial carcinomas accounted for 76.7% , which was statistically higher than that of normal ovarian 15.0% （P 〈 0.05 ）. The positive expressions of CDll7 and Ki67 in high-grade group were significantly higher than those in low- grade group （ P 〈 0.05 ）., and the two indexes increased with the advancing International Federation of Gynecology and Obstetrics （FIGO） stages and residual tumor size （ P 〈 0.05 ）. There was no significant correlation between CD117 and Ki67 expression. Conclusion The expressions of CD117 and Ki67 are aasociated with histological grades of the ovarian epithelial nebplasm. The detection of CD117 and Ki6＂/may be helpful to the estimation of the malignant degree and prognosis of the epithelial ovarian carcinoma.