摘要
目的阐明骨质疏松性胫骨骨折愈合过程超微结构的变化，探索骨质疏松性骨折愈合的形态学基础。方法健康 SD大鼠，随机分卵巢切除（ OVX）组和假手术（ S）组。 1月后，所有动物作胫骨骨折模型。分别于骨折后不同时间处死取材。通过光镜观察骨折修复过程中骨痂组织学改变；通过电镜观察成骨细胞及破骨细胞的形态及活性。结果 OVX组与 S组在骨痂形成早期骨痂形态、骨痂密度及成骨细胞、破骨细胞活性有明显差异。结论卵巢切除后，胫骨骨折愈合缓慢。雌激素在骨折愈合过程中起重要作用。
Objective To study the effects of ovariectomy on ultrastructure of tibia fracture healing of the osteoporosis, and search the morphologic basis of osteoporotic fracture.Method 96 Female SD rats were divided randomly to normal contrast group (Sham－ operation S), ovariectomy group(OVX),fracture were made in shaft of tibia in all rats. Calluses and soft tissues were collected at different times after fracture. Observe the histology changes of calluses by microscope and activity of osteoblasts、 osteoclasts by electron microscope. Results OVX group is different with S group in callus density and morphology, activity of osteoblasts and osteoclasts. Conclusion Tibia fracture healing delays after ovariectomy.Estrogens play an important role in fracture healing.
出处
《现代康复》
CSCD
2000年第12期1840-1841,共2页
Modern Rehabilitation
