乳腺恶性淋巴瘤形态学及免疫组织化学研究

Morphologic and immunohistochemical study of mammary malignant lymphoma

目的:研究乳腺非霍奇金淋巴瘤(NHL)的组织形态特点及免疫表型.方法:对17例乳腺NHL作形态学分析,其中11例进行了免疫学标记.结果:13例为原发性,4例为继发性.8例(47.06%)见“淋巴上皮病变”,13例(76.47%)见肿瘤浸润脉管,4例(23.53%)伴有“淋巴细胞性乳腺病”,3例(17.65%)见局部瘤细胞呈靶环样排列.免疫组化示16例(94.12%)为B细胞NHL,其中2例(12.50%)KP1阳性,1例(6.25%)UCHL-1阳性.结论:(1)大多数乳腺原发性NHL为MALT型淋巴瘤;(2)淋巴细胞性乳腺病可能是一些乳腺NHL的前驱病变;(3)少数B细胞NHL能与KP1或UCHL-1发生交叉反应.

Objective: To investigate the histologic features and immunophenotypes of non-Hodgkin's lymphoma (NHL) of the breast. Methods: Seventeen cases of mammary NHL were analysed morphologically, in which eleven cases were studied by im-munohistochemical techniques. Results: Thirteen cases were primary, four were secondary. There were 8(47.06%) cases with' lymphoepithelial lesions', 13(76.47%) with tumor invasing vessels, 4(23.53%) with lymphocytic mastopathy; 3(17.65%) with targetoid patten. Immunohistochemically. 16 cases(94.12%) were B cell NHL. Of which, 2(12.50%) were KP1 positive, 1 (6.25 % ) were UCHL - 1 positive. Conclusions: (1) The majority of primary NHL of breast are mucosa - associated lymphoid tissue type lymphomas. (2) Lymphocytic mastopathy might be an antecedent of some mammary NHL. (3) A few B cell NHL can be stained with KP1 or UCHL- 1 because of crossreactivity.