多种肿瘤标记物在卵巢恶性肿瘤化疗期间的监测作用

Application of multi - tumor markers in ovarian carcinoma during chemotherapy

目的:探讨卵巢恶性肿瘤患者术后化疗期监测CA_(125)、CA_(19-9)、CA_(27-29)及铁蛋白(Fer)的价值.方法:对55例卵巢恶性肿瘤患者在第一年的6周期化疗前、后分别进行血清标志物检测.结果:在晚期卵巢恶性肿瘤患者及化疗期复发者,CA_(125)及CA_(27-29)在6周期化疗后仍继续上升;而早期卵巢恶性肿瘤患者及化疗期无复发者这两种标记物在6周期化疗后下降.结论:在卵巢恶性肿瘤患者手术后对预后的估计及化疗期间的随访中CA_(125)和CA_(27-29)较CA_(19-9)和Fer起着更为重要的作用.

Objective:The four tumor markers CA_(125)?CA19-9?CA_(27-29) and Ferritin were used to follow up the ovarian carcinoma patients during their chemotherapy. Methods:Sera obtained from patients before and after chemotherapy in the first year,Serologic ex-amination of four tumor markers CA_(125)?CA19-9?CA_(27-29) and Fer were performed. Results: For the late - stage and recurrence pa-tients, the CA_(125) and CA_(27-29) grew up after chemotherapy;but for the early- stage and no?recurrence patients, the CA_(125) and CA_(27-29) descent after chemotherapy. Conclusion: CA_(125)?CA_(27-29) can do an important part in detecting of recurrence of the ovarian carcinoma patients and should be followed up during chemotherapy.