支气管动脉灌注栓塞化疗治疗肺癌所致上腔静脉综合征

Bronchial arterial infusion chemotherapy and embolization in the treatment of superior vena cava syndrome caused by lung cancer

目的:评价支气管动脉灌注栓塞化疗(BAIE)在治疗肺癌所致上腔静脉综合征(Superior vena cava syndrome,SVCS)中的作用.方法:32例肺癌所致SVCS患者,其中小细胞肺癌18例,鳞癌11例,腺癌3例,随机分成两组.A组给予BAIE,B组给予放疗.结果:A组SVCS症状完全消失10例,好转4例,有效率87.5%(14/16),从BAIE到症状完全消失平均5.6天;B组SVCS症状完全消失9例,好转5例,有效率87.5%(14/16),从放疗开始到症状完全消失平均15.6天,两组有效率相比无显著差异(P>0.05),但症状消失时间A组较B组短,有显著差异(P<0.05).结论:BAIE可以迅速缓解SVCS症状,有效率高,尤其适用于小细胞肺癌引起的SVCS.

Objective:To evaluate the effect of bronchial arterial infusion chemotherapy and embolization(BAIE) in the treat-ment of superior vena cava syndrome( SVCS). Methods: 32 cases including 18 small cell lung cancers, 11 squamous cell carcinomas, 5 adenocarcinoma with SVCS were divided randomly into group A and group B. Group A was treated by BAIE and group B was treated by radiotherapy. Results: In gropu A, 10 patients with SVCS achieved complete remission and 4 patients partial remission after the first treatment of BAIE. The total effective rate was 87.5% . In gropu B, 9 patients with SVCS achieved complete remission and 5 patients partial remission. The total effective rate was 87.5%(P>0.05).Conclusion:BAIE is an effective,quick and safe therapy in the treatmnet of SVCS caused by lung cancer, especially by small cell lung cancer.