益气活血方对动脉粥样硬化模型兔血脂及动脉结构的影响

EFFECT OF PRESCRIPTION OF SUPPLEMENTING QI AND ACTIVATING BLOOD CIRCULATION ON ATHEROSCLEROTIC RARRIT SERUM LIPID AND ATERIAL STRUCTURE

目的 探讨益气活血方对动脉粥样硬化（ＡＳ）及动脉结构的影响。方法 ３２只新西兰大白兔随机分为四组：正常对照组、高脂对照组、益气活血预防组及益气活血治疗组，观察时间为二月。治疗前后进行血脂分析，治疗结束取主动脉组织作脂质及钙定量，并对主动脉作病理学检查，测量动脉管壁厚度、内膜厚度、管壁面积、内膜面积及管腔面积。结果１．益气活血方治疗可以降低模型兔血胆固醇、甘油三酯、低密度脂蛋白胆固醇，使动脉内甘油三酯水平显著降低，但对主动脉内钙含量无明显影响。２．益气活血治疗减少模型动物粥样硬化的形成，使内膜面积、厚度减少，但对管腔面积无明显影响。结论 益气活血方具有降低血脂和抑制ＡＳ形成的作用。

Objective To investigate the effect of prescription for supplementing qi and activating blood circulation on serum lipid and arterial structure of atherosclerotic rabbit.Methods 32 New Zealand rabbits were randomized into four groups: normal control group, hyperlipidemia control group, traditional medicine preventive group and traditional medicine treatment group. Each group was observed for two months. Serum lipid was tested before and after treatment. After treatment, aortic tissue was taken for quantitative estimation of lipid and calcium, and also for pathophysiological analysis, including vascular wall thickness, intimal thickness, vascular wall area, intimal area and arterial lumina area. Results 1. Prescription for supplementing qi and activating blood circulation plays an important role in lowering TC, TG and LDL- TC in AS rabbits. 2 .This prescription is capable of lowering intimal area and intimal thickness, thus inhibiting AS formation. Conclusions Prescription for supplementing qi and activating blood circulation can lower serum lipid and inhibit AS formation.