代谢组学在中药质量与药效研究中的应用

The Application of Metabolomics in Research of Traditional Chinese Medicine Quality and Pharmacodynamics

代谢组学是20世纪90年代末期发展起来的一门新兴学科,着重研究生物整体、器官或组织的内源性代谢物质的代谢途径及其所受内在或外在因素的影响及随时间变化的规律。随着发展,代谢组学在药物研发、中药研究与评价、临床诊断、毒理学研究、微生物与植物、营养科学等领域中的应用越来越广泛。本文主要综述代谢组学的研究手段与方法在中药质量控制研究和中药药效研究中的应用状况,并展望其在中医药研究领域的应用前景。

biological overall Metabolomics organ or tissue internal or external factors. With research, Traditional Chinese is an emerging discipline which developed in the end of the 1990s. It focuses on metabolic pathways of endogenous metabolites, the rules of changes caused by the technology development, metabolomics is more and more widely used in drug Medicine research and evaluation, clinical diagnostics, toxicology studies, microorganisms and plants, nutrition science. This article reviews the application status of metabolomics research tools and methods in the study of Traditional Chinese Medicine quality control and pharmacodynamics, and the prospects of their application in Traditional Chinese Medicine.