鞣质类化合物在口腔领域中的作用

Application of tannins in the dental and oral fields

鞣质系指能生成皮革的槲树皮内的成分,广泛存在于植物界中,具有抗菌、抗病毒、抗肿瘤、抗氧化,保护黏膜,止血,收敛等多种生理活性,可抑制致龋菌的生长和黏附,使其产酸能力得到遏制,葡糖基转移酶活性降低;可使蛋白质凝固,减轻牙髓细胞所受到的脂多糖的毒性作用;降低微渗漏,提高根管治疗率;对于外伤后恒牙的保髓和活髓切断预后均有较好的辅助作用;对于牙龈炎和牙周疾病的治疗效果良好;可明显减轻疱疹性口炎、口腔溃疡疼痛,促进溃疡面愈合;可防治口腔颌面部外伤、外伤感染,促进烫伤、灼伤和烧伤等创面愈合;可通过增强机体的免疫功能抑制肿瘤生长,诱导肿瘤细胞程序性死亡,降低皮肤和其他器官发生肿瘤的危险。

Tannins, which are extracted from oak bark to produce leather, widely exist in the plant kingdom and exhibit various physiological properties, such as bacteriostatie, antivirus, antitumor, antioxidation, mucous membrane protection, hemostasis and convergence. Tannins can inhibit cariogenic bacteria growth and adhesion, check the ability for acid production, and decrease glucosyltransferase activity. Tannins can induce the protein to coagulate, whereas the toxic effects attenuate lipopolysaccharide by dental pulp cells. Tannins can also reduce micro-leakage, improve the success rate of root canal therapy to complement the prognosis, and provide good protection and pulp teeth pulpotomy after trauma. The application of tannin on gingivitis and periodontal disease treatment is good because it can significantly reduce herpetic stomatitis and oral ulcer pain, promote ulcer healing, and simultaneously prevent and treat oral and ma^illofacial trauma, trauma infection, promote scald, bums, and burn wound healing. Notably, tannins can enhance the immune function of inhibiting tumor growth, inducing tumor cell apoptosis, and reducing the risk of tumors of the skin and other organs.