山东省济南市健康成人呼出气一氧化氮参考值范围

Reference range of fractional exhaled nitric oxide for healthy adults in Jinan city, Shandong province

目的探讨山东省济南市健康成人呼出气一氧化氮（FeN（））的正常值范围，为慢性气道炎症的诊断与治疗提供参考依据。方法随机抽取山东省济南市200名健康成人（无吸烟史，无过敏性疾病史，近2周无上呼吸道感染病史，心肺功能检测及血IgE筛查无异常）。按年龄段分为5组，分别为：A组16～19岁，B组20～29岁，c组30～39岁，D组40～59岁，E组60～80岁，每组男女各20人。依据ATS指南（2009），采用瑞典尼尔斯FENO测定系统测定FENO值。以SPSS18．0统计包进行统计分析。结果整体及男女两组均不符合正态分布（P〈o．05）。存在性别差异，男性显著高于女性（P〈O．01）。按年龄分组各组间差异无统计学意义（P〉0．05）。应用百分位数法确定95％范围，按性别分组并取双侧正常值范围，女性为8～31ppb，男性为9～39ppb。结论山东省济南市健康成人FeNO值存在性别差异，男性高于女性，临床应用时应予以考虑。

Objective To explore the reference range of exhaled nitric oxide （FeNO） for healthy adults in Jinan city,Shandong province,provide reference for the diagnose and treatment of chronic airway inflammation. Methods 200 healthy adults （non-smoking, no history of allergic diseases, no history of upper respiratory tract infection in the last two weeks, normal lung and heart function testing, normal serum IgE） in Jinan city were randomly selected. They were divided into five groups by age （A group： 16- 19 years old, B group：20-29 years old, C group：30-39 years old, D group：40 59 years old, and E group： 60-80 years old）. Each group had 20 men and 20 women. FEN（） was measured at an exhalation flow rate of 50 ml/s with a rapid-response chemilumineseent analyzer （NIOX system, Aeroerine, Sweden） following ATS guidelines （2009）. SPSS 18.0 for windows statistical package was used for statistical analysis. Results The data before and after grouping were non normal distribution （ P 〈0.05）. FeNO of men was significantly higher than that of women （ P〈0.01）, and there was no significant difference in FENO among the five age groups （ P〈0.05）. The 95% reference range was determined by percentile method and the bilateral ranges were taken for data grouped by gender. The reference range of FeNO was 8-31 ppb for normal women and 9-39 ppb for normal men. Conclusions FENO value of healthy men is higher than that of women in Jinan city, Shandong province. The difference should be considered in clincal application.