参与类风湿关节炎间质性肺疾病发病的细胞因子

Cytokines involved in rheumatoid arthritis interstitial lung diseases

类风湿关节炎（rheumatoidarthritis．RA）易于合并间质性肺疾病（interstitiallungdisease，ILD），其缺乏有效治疗手段，病死率高，危害大。RA—ILD发病机制不明，有假说推测初始激活因素激活肺部居留细胞释放促炎性细胞因子和趋化因子浸润肺组织，导致肺泡炎，炎细胞产生促纤维化介质，促进细胞外基质沉积并破坏肺泡及间质正常解剖结构，最终导致严重的结构和功能紊乱。近年来，人们陆续发现了多种细胞因子参与RA—ILD发病的直接证据，证实r细胞因子参与了RA—ILD的发病过程，本文对此进行综述。

Interstitial lung disease （ILD） is commonly accompanied with rheumatoid arthritis （RA） ,and lack of effective treatment, so the mortality of the disease is high. The pathogenesis of RA- ILD is unclear, it has been hypothesized that the initial activation factors may activate the resident cells in lung tissue to release pro-inflammatory cytokines and cause alveolitis, then, the inflammatory cells produce pro-fibrotic media to promote extracellular matrix deposition and alveolar and interstitial cells damage, the normal lung anatomic structure disappear, eventually lead to severe structural and functional disorders. In recent years, researchers have been discovered some direct evidences to conform that a variety of cytokines are involved in the pathogenesis of RA-ILD, the advanced researches of cytokines and RA-ILD are discussed in this article.