摘要
<正> 胆红素IX_α(胆红素)是哺乳动物体内血红素的代谢产物,由于它与小儿黄疸病光疗的直接关系,以及近来发现它在体内可能作为生物抗氧剂,所以一直受到科学家的重视。在非质子溶剂中胆红素的光氧化可以生成胆绿素IX_α(胆绿素)及一系列单吡咯、双吡咯的衍生物。对于生成单、双吡咯小分子衍生物,用类型Ⅱ(~1O_2为中间体)的光氧化机制很好解释,但对胆绿素的生成到底是经过单重态氧途径,还是离子自由基途径尚不完全清楚。
Hypocrellin A sensitized photooxidation of bilirubin in aprotic solvent, dichlorometh-ane, gave biliverdin and other degraded molecules. The yield of biliverdin was varied with concentration of bilirubin, irradiation time and light intensity. A highest yield was readied to 58%. The photooxidation pathway is 1O2 intermediated Type II, 'ene addition' of singlet oxygen at C10-C12 of bilirubin via bis-free radical intermediate may lead to formation of biliverdin.
出处
《感光科学与光化学》
CSCD
1991年第1期58-61,共4页
Photographic Science and Photochemistry
基金
国家自然科学基金
关键词
胆红素
胆绿素
竹红菌甲素
光氧化
bilirubin, biliverdin, hypocrellin A, dichloromethane, photooxidation
