816例不同吸烟状况肺癌患者临床特点分析

Clinical characteristics of lung cancer patients with different smoking status:An analysis of 816 cases

目的探讨不同吸烟状况肺癌患者的临床特点、疗效和生存率。方法回顾性分析2007年2月～2010年2月在我院住院诊治的816例肺癌患者，比较两组肺癌病例在年龄、性别、病理类型、分期、近期疗效及生存率等方面的差异。结果两组比较，观察组患者按照性别计算发病率高于对照组，差异具有统计学意义（P〈O．05），而年龄、居住地对于发病的影响不明显，差异无统计学意义（P〉0．05）。同组间比较，观察组男性发病率高于女性，40岁以上发病率高于40岁以下，差异具有统计学意义（P〈0．01）。对照组间40岁以上发病率高于40岁以下，差异具有统计学差异（P〈0．01）。观察组病理类型中以鳞癌居多，病理分期多见Ⅲ期；对照组患者中则以小细胞肺癌常见，病理分期亦多见Ⅲ期。两组患者治疗后，观察组的有效率为60．95％，低于对照组的63．81％，差异无统计学意义（P〉0．05）。观察组1年生存率低于对照组，差异具有统计学意义（P〈0．05），而3年生存率则进一步降低，差异具有显著统计学意义（P〈0．01）。结论中老年男性吸烟者是肺癌高发人群，多发鳞癌Ⅲ期，预后不佳，控制吸烟应是防治肺癌及提高生存率的有效措施。

Objective To discuss different smoking status lung cancer patients＇ clinical characteristics, curative effects and survival rates. Methods Retrospectively analyzed 816 cases patients, who were treated in our hospital from Feb. 2007 to Feb. 2010, compared two groups lung cancer cases＇ differences in age, sex, pathological type, stage, recent cu- rative effect and survival rate. Results Compared the two groups, if calculated incidence of a disease by sex, the obser- vation group patients were higher than control group, the difference has statistical significant （P 〈0.05）, but age, domi- cile weren＇t obvious effects to be taken bad, the difference hasn＇t statistical significant（P 〉0.05）o If compared within the group, in observation group male incidence of a disease was higher than female, 40 years old or above patients＇ in- cidence of a disease was higher than below 40 years old, the difference has statistical difference （P 〈0.01）. In control group, 40 years old or above patients＇ incidence of a disease was higher than below 40 years old, the difference has statistical difference （P 〈0.01）. In observation group＇s pathological type, Squamous Cells Carcinoma were mainly, pathological stage mainly were third stage; but in control group, mainly were small cell lung cancer, pathological stage mainly were third stage. After treated two group patients, observation group＇s effective rate was 60.95%, lower than control group＇s 63.g1%, the difference hasn＇t statistical difference （P 〉0.05）. The observation group＇s one year sever- al rate was lower than control group, the difference has statistical difference （P 〈0.05）, but three year several rate was further lower, the difference has statistical difference （P 〈0.01）. Conclusion Middle-aged male smokers are lung can- cer, high-risk groups multiple squamous cell carcinomas 11I period, control smoking is the effective measure to prevent lung cancer and improve the survival rate.