福建省280例复治肺结核患者耐药监测结果分析

Analysis of drug resistance survey results of 280 patients with retreated pulmonary tuberculosis in Fujian province

目的分析福建省耐药监测点纳入的280例复治肺结核患者在不同年龄组的耐药情况,为结核病临床治疗和控制工作提供参考。方法收集一定时间段内在结核病门诊登记的复治结核病患者的痰液,经涂片镜检、分离培养后,用国家推荐的比例法对培养阳性的菌株进行菌型鉴定和一线抗结核药物的敏感性测定。结果 280例复治病例的总耐药率36.78%,其中耐单药率为12.5%,多耐药率为8.57%,耐多药率为15.71%,各年龄组耐单药率(χ2=3.69,P>0.05)、多耐药率(χ2=6.52,P>0.05)、耐多药率(χ2=10.56,P>0.05)差别无统计学意义。结论福建省复治肺结核患者耐药疫情虽然在国内处于较低水平,但是青壮年耐药情况有上升趋势,要引起足够的重视。

Objective To analyze the drug resistant information of 280 cases of retreated pulmonary tuberculosis at different ages in Fujian province, and provide reference for tuberculosis treatment and control. Methods The sputum of retreated PTB patients registered in tuberculosis clinic were collected to conduct sputum smear microscopy and culture, then the culture positive strains were conducted bacterial identification and drug susceptibility test of first line anti - tuberculosis drugs. Results Among the 280 retreated patients, the total drug resistant rate was 36.78%, the mono -drug resistant rate was 12.5%, the multi -drug resistant rate（ excluding simultaneous resistance to H and R） was 8.57%, and multi -drug resistant rate（ including resistance to H, R） was 15.71%, there were no significant difference in the above resistant rates among different age groups （χ^2 =3.69, P〉0.05;χ^2 =6.52, P〉0. 05;χ^2 = 10.56, P〉0.05）. Conclusion The retreated PTB cases showed low-level resistance in Fujian province, but more attention still need to pay to the epidemic of drug resistant tuberculosis, especially in young people.