二氢卟吩P_6酰胺衍生物在重水中对NADPH光氧化作用的敏化效应

Sensitizing Effects of Chlorin P_6 Amides on Photooxidation of NADPH in D_2O

报道二氢卟吩 P6酰胺衍生物 la～e在重水中对 NADPH光氧化作用的敏化效应。实验结果表明 ;la～ e在非细胞体系中的光敏化力均优于参比药物血卟啉衍生物 ( HPD) ,以 1c为最强 ;提示

In this paper the sensitizing effects of chlorin P 6 amides (1a～e) on photooxidztion of NADPH in deuterium-oxide were determined.The results of preliminary experiment showed that photosensitizing ability in cell-free system of all chlorin P 6 amindes (1a～e) were much higher than that of hematoporphyrin derivatives(HPD).Among them,1c possesses the highest photosensitizing activity.It is suggested that 1c is possible to be developed as a new photosensitizers for photodynamic therapy (PDT) of cancer.