海洛因成瘾者神经免疫功能的损害

A preliminary study of correlation between neuro and immunine function in heroin addicts

目的 :探讨海洛因成瘾者神经 免疫功能损害的原因及两系统间相互作用的关系。方法 :应用RIA法测定 45例海洛因成瘾者和 40例正常人血清中 β 内啡肽 (β EP)、促肾上腺皮质激素 (ACTH)和干扰素α(IFNα)。结果 :海洛因成瘾组β EP、IFNα含量较正常组显著降低 (P <0 0 1,P <0 0 0 5 ) ,ACTH含量比正常组显著升高 (P <0 0 1)。结论 :①海洛因成瘾者神经系统损害的原因与外源性吗啡与脑内神经细胞受体结合引起内源性 β EP含量降低有密切关系 ;②外源性吗啡可直接与免疫细胞的吗啡受体结合 ,抑制免疫细胞活性 ,造成其分泌IFNα降低 ,影响免疫功能 ;③内源性 β EP含量降低 ,与免疫细胞上受体结合减少 ,对其激活作用降低 ,影响IFNα分泌 ,减弱免疫功效。IFNα含量降低 ,与脑内细胞上的受体结合减少进一步抑制 β EP的分泌 。

Objective:To investigate the injury of neuro system and immune system in herion addicts.Methods:Serum content of β EP,ACTH and IFN was detected with radioiimmunoassay in 45 heroin addicts and 40 non heroin users as control.Results:Concentration of β EP and IFN in heroin addicted group significantly decreased (P<0.01;P0.005) compared with that of the control.The content of ACTH in heroin addicted group was higher than that of the control(P<0.01).Conclusion:The results suggested that the function of neuro and immune system were affected by heroin ,which result in the decreasing of secretory function by some neuro immune cells.