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Rhupus综合征1例并文献复习

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摘要 目的分析Rhupus综合征的发病机制及临床特点。方法对1例类风湿关节炎(RA)重叠系统性红斑狼疮(SLE)的Rhupus综合征患者的病例资料进行分析,复习相关文献并总结临床最新研究进展。结果 1例女性,有月经紊乱史,以RA为首发表现,经17年的RA病程才出现SLE特征性表现,就诊时关节症状严重并出现关节畸形,血沉(ESR)、C-反应蛋白(CRP)及类风湿因子(RF)水平均明显升高,抗Sm抗体和抗双链DNA抗体阳性,补体C3、C4水平明显降低,累及血液系统及肾脏,分别表现为自身免疫性溶血性贫血及肾病综合征,联合应用泼尼松、羟氯喹治疗后病情好转。结论 Rhupus综合征患者的关节症状严重,致畸率高,可累及血液、肾脏及脑等内脏系统,对高危患者应规律随访,监测临床及实验指标,早期合理治疗,可明显改善患者预后。
作者 古金华
出处 《临床医学》 CAS 2013年第11期61-63,共3页 Clinical Medicine
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参考文献17

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