齐拉西酮合并舍曲林治疗精神分裂症阴性症状的疗效和不良反应

Efficacy and adverse reactions of ziprasidone combined with sertraline in the treatment of negative symptoms of schizophrenia

目的探讨齐拉西酮联合舍曲林治疗精神分裂症阴性症状的临床疗效。方法将娄底市中心医院2011年1月至2012年1月收治的114例精神分裂症阴性症状患者随机分为两组,其中对照组单纯采用齐拉西酮,观察组采取齐拉西酮联合舍曲林治疗,比较两组临床治疗效果及不良反应发生情况。结果观察组总有效率为85.96%,明显高于对照组的61.40%(P<0.05);两组治疗后PANSS总分均较治疗前明显减少,且观察组减少更为显著(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论齐拉西酮联合舍曲林可明显缓解精神分裂症患者的阴性症状,且不良反应少,依从性好,值得临床推广和应用。

Objective To investigate the efficacy of ziprasidone combined with sertraline on negative symptoms of schizophre- nia. Methods The patients with negative symptoms of schizophrenia treated in Loudi central hospital from January 2011 to 2012 were randomly divided into two groups, the patients in control group were treated with ziprasidone, while the patients in observa- tion group were given ziprasidone combined with sertraline, the clinical efficacy and adverse events were compared between the two groups. Results The total effective rate of the observation group was 85.96%, which was significantly higher than that of the control group（64.40% ）, P 〈0. 05 ; The total scores of PANSS in the two groups after treatment significantly reduced than before, and the observation group decreased more significantly （ P 〈 0. 05 ） ; There was no significant difference in the incidence of adverse reactions between the two groups （P 〉 0. 05 ）. Conclusion Ziprasidone combined with sertraline can significantly al- leviate the negative symptoms of schizophrenia, and it has few adverse reactions, has good compliance, and it is worth to be pro- moted and applied in clinics.