氨溴特罗口服液治疗儿童咳嗽变异性哮喘疗效观察

Therapeutic effect of ambroxol hydrochloride on children with cough variant asthma

目的观察氨溴特罗口服液治疗儿童咳嗽变异性哮喘的疗效。方法将150例咳嗽变异性哮喘患儿随机分为对照组和观察组,每组75例,对照组口服孟鲁司特钠及舒喘灵片,观察组口服孟鲁司特钠及氨溴特罗口服液,比较两组疗效。结果观察组咳嗽消失时间明显短于对照组(P<0.05);观察组总有效率(89.3%)高于对照组(76%),两组比较差异有统计学意义(χ2=4.6526,P<0.05);对照组不良反应发生率高于对照组(χ2=4.7535,P<0.05)。结论氨溴特罗口服液在儿童咳嗽变异性哮喘治疗中疗效显著,且不良反应少,值得临床推广。

Objective To observe the therapeutic effect of ambroxol hydrochloride on children with cough variant asthma. Methods One hundred and fifty children with cough variant asthma were randomly divided into treatment group and control group, with 75 cases in each group. The control group was treated with montelukast sodium and salbutamol tablets, and the treat- ment group was treated with montelukast sodium and ambroxol hydrochloride. Results The cough disappeared time of the treat- ment group was significantly shorter than that of the control group（P 〈0. 05 ）. Efficacy rate of treatment group and control group was 89. 3% and 76% , respectively, there was significant difference in clinical efficacy between the treatment group and the con- trol group（ X2 = 4. 6526 ,P 〈 0.05 ）. Adverse reaction rate in control group was higher than that in control group（ X2 = 4. 7535, P 〈 0. 05 ）. Conclusion Ambroxol hydrochloride is effective and safe to treat cough variant asthma of children. It should be widely applied in the clinic.