^(99m)Tc-植酸钠扫描评价猪异位肝移植后两肝功能状况

Evaluation of liver function with ^(99m)Tc-phytate scintigraphy after heterotopic liver transplantation in pig

目的 观察99mTc -植酸钠扫描检测异位肝移植后两肝功能状况。方法 建立猪右肝下部分肝移植模型 ,部分捆绑缩窄宿主门静脉控制两肝门静脉血流 ,术后通过99mTc -植酸钠扫描检测两肝血流量 ,并与组织学相对照 ,观察99mTc -植酸钠扫描的实用价值。结果 99m Tc -植酸钠扫描检测的肝功能状况与组织学结果符合 ,门静脉缩窄 1/3组 (A组 )两肝血流量较均衡 ,移植肝及宿主肝均无萎缩 ,门静脉缩窄 1/2组 (B组 )宿主肝血流量明显低于移植肝 ,宿主肝萎缩 ,门静脉无缩窄组 (C组 )移植肝血流量明显低于宿主肝 ,移植肝萎缩。结论 99m Tc -植酸钠扫描能准确反映异位肝移植后两肝功能状况 。

Objective To evaluate the live function with 99m Tc-phytate scintigraphy after heterotopic liver transplantation in pig. Methods The graft was transplanted in the right subhepatic space of recipient to establish pig heterotopic partial liver transplantation model with its host portal vein partially constricated near host liver. Trussing was used to control graft and host liver blood flow. the functions of graft and host liver were evaluated by 99m Tc-phytate scintigraphy after heterotopic liver transplantation and were compared with histology. Results The functions of graft and host liver evaluated by 99m Tc-phytate scintigraphy were correspondent with histology. In group A, the liver blood flows were almost equilibrated in graft and host liver. Both livers were not atrophic. The blood flow of host liver was significantly less than that of graft liver in group B and the host liver was atrophic. However, the blood flow of graft liver was significantly less than that of host liver in group C and the graft liver was atrophic.Conclusion 99m Tc-phytate scintigraphy can accurately reflect the functions of graft and host livers after heterotopic liver transplantation and it is a reliable means for to investigating liver functions.