血清CysC、HCY和hs-CRP检测在糖尿病肾病中的诊断价值

Diagnostic value of serum cystatin C,homocysteine and high sensitivity C-reactive protein in diabetic nephropathy

目的:探讨血清胱抑素C(Cys C)、同型半胱氨酸(HCY)、超敏C反应蛋白(hs-CRP)联合检测在糖尿病(DM)患者肾损害中的诊断价值。方法:研究175例DM患者和40例健康对照者的血清Cys C、HCY、hsCRP水平变化。血清Cys C和hs-CRP采用乳胶颗粒增强免疫比浊法,血清HCY采用循环酶法测定。结果:DM患者正常白蛋白尿组的血清Cys C、HCY、hs-CRP水平较对照组明显升高(P<0.05),DM患者微量白蛋白尿组和临床蛋白尿组较对照组血清Cys C、HCY水平升高显著(P<0.01),血清Cys C、HCY、hs-CRP水平随糖尿病肾病(DN)的发生以及严重程度逐渐增高。结论:血清Cys C、HCY和hs-CRP检测可作为早期诊断DN较敏感的指标;对监测早期DN的发生和病情发展程度有重要意义。

Objective：To study the diagnostic value of the combined detection of serum cystatin C （Cys C） ,ho- mocysteine （HCY） and high sensitivity C-reactive protein （hs-CRP）in diabetic nephropathy. Method： The changes of serum Cys C, HCY and hs-CRP in 175 cases of DM patients and 40 healthy control group were compared. The serum Cys C and hs-CRP were conducted by using latex particle enhanced immunoturbidimetric assay, the serum HCY was conducted by using cycle enzymatic assay. Meanwhile, the rates of combined detection were analyzed. Re- suit： DM patients with normal albuminuria group, serum Cys C, HCY and hs-CRP level were significantly higher than those of normal control group （P〈0.05）, serum Cys C and HCY levels were higher significantly （P〈0.01） in DM patients with microalbuminuria and clinical proteinuria than normal control group, the level of serum Cys C, HCY and hs-CRP gradually increased with the occurrence and severity of diabetic nephropathy. Conclusion：The de- tection of serum Cys C, HCY and hs-CRP could be used as a sensitive indicator for early diagnosis of DN and moni- toring the occurrence of early DN and the degree of progression of the disease.