血清胱抑素C对2型糖尿病肾病的临床诊断价值

Clinical diagnosis value of serum CysC to type-2 diabetic nephropathy

目的:探讨血清胱抑素C(CysC)对2型糖尿病肾病的临床诊断价值。方法:随机收集2型糖尿病住院患者49例,将患者分为单纯2型糖尿病组(26例)和糖尿病并发肾病组(23例),另设正常对照组(32例)。采用乳胶颗粒增强免疫透射比浊法测定血清CysC的浓度,并与24h尿白蛋白做相关性分析。结果:糖尿病并发肾病组和单纯2型糖尿病组CysC显著高于对照组,差异有统计学意义(P<0.05);糖尿病并发肾病组的CysC和24h白蛋白显著高于单纯2型糖尿病组,差异有统计学意义(P<0.05)。糖尿病并发肾病组中,中晚期肾病亚组的CysC和24h尿白蛋白显著高于早期肾病亚组,相关性分析显示,CysC与24h尿白蛋白呈正相关(r=0.751,P=0.000)。结论:血清CysC水平对糖尿病肾病的诊断有重要价值,血中CysC的浓度可作为反映糖尿病肾病患者肾损害的良好指标。

Objective：To discuss the clinical diagnosis value of serum CysC to type 2 diabetic nephropathy. Method：49 cases of type 2 diabetic nephropathy were randomly collected and divided into two groups,namely simplex type 2 diabetic （26） and diabetic nephropathy （23）. And common control group were 32 cases. Serum CysC level was detected with La- TeX particle reinforced immune transmission turbidimetry. The correlation between serum CysC level and 24 hour urine albumin was analyzed. Result： CysC in Diabetic Nephropathy group and simplex type 2 diabetic group were dramatically higher than that of common control group which difference had statistics significances（P〈0.05）, The analysis of 50 Dia- betic Nephropathy showed that CysC and 24 hour urine albumin in the group of the late or advanced stage nephroma were dramatically higher than those of the group of early stage nephroma. The correlation analysis showed that CysC and 24 hour urine albumin had a positive correlation（r= 0. 751 ,p=0. 000）. Collchtsion： Level of serum CysC could have promi- nent value to diabetic nephropathy diagnosis, which could be a good index reflected on early kidney damage of diabetic ne- phropathy.