血栓调节蛋白在成人及胎肺组织中的表达

EXPRESSION AND LOCALIZATION OF THROMBOMODULIN IN HUMAN FETAL LUNG

目的 研究血栓调节蛋白在成人肺组织及胎肺组织中的表达意义。 方法 以发育 18周的人胎肺组织、正常成人肺组织为研究对象 ,应用免疫组织化学 SP法检测血栓调节蛋白的存在。 结果 在 18周人胎肺组织中 ,血栓调节蛋白表达于围绕原始肺泡上皮细胞团周围的血管内皮细胞中 ,在原始肺泡上皮细胞及原始支气管上皮细胞、软骨均呈阴性表达。正常成人肺组织内的血管内皮细胞呈阳性表达。 结论 血栓调节蛋白在人胎中期肺组织中未见表达。

Objective\ To detect thrombomodulin protein in 18 weeks human fetal lung. Methods\ SP method was used in the study. Results\ It showed that, in fetal lung tissues, thrombomodulin expressed in the endothelial cells of capillaries surrounding the primary alveoli, but it was absent in cuboid cells and ciliated\|columnary epithelium cells and cartilage. Conclusion\ Our results suggest that thrombomodulin does not exist in middle and late stage's human fetal lung.\;