生长抑素在乳腺癌中的表达及其临床意义

Expression of somatostatin(SST) in breast cancer

目的 探讨生长抑素 (sst)在乳腺癌中诊断和治疗的价值。方法 应用免疫组织化学方法对 30例原发性乳腺癌患者行sst和ERPR的表达。结果 有同侧腋窝淋巴结转移患者 11例 ,其中 8例sst(+ ) ;无同侧腋窝淋巴结转移者 19例 ,其中 7例sst(+ ) ,两组差异有显著性 (χ2 =3 .6 ,P <0 .0 5 )。良性乳腺瘤 10例 ;其中 4例sst(+ )与 2 0例乳腺癌sst(+ )相比 ,两组差异有非常显著性 (χ2 =9.2 2 ,P <0 .0 1)。

Objective To evaluate the expression of Somatostatin(SST) in diagnoses and Treatment of breast cancer.Method 30 cases of primary breast cancer were studied in expression of Somatostatin(SST) and ER, PR with Immunohistochemicaty assay.Result 20 cases of patients in total 30 cases demonstrate SST positive. 8 SST positive in 19 patients with lateral lymph node negative. ( χ 2= 3.6 P < 0.05 ). Compared with 10 cases of benign lesion of breast in which 4 cases show SST positive, 20 cases show SST positive in 30 cases of malignant lesions( χ 2= 9.22 P < 0.01 ).Conclusion Somatostatin(SST) plays a role diagnosis and treatment of primary breast cancer, but had better prognosis in patients with SST breast cancer. [