高强度超声治疗早期兔肝脏肿瘤

High intensity ultrasound in the treatment of early rabbit liver cancer

目的 探讨高强度超声 (HIU)治疗早期兔肝VX2 肿瘤 (病毒诱导的兔鳞癌 )的有效性和安全性。方法 实验分 3组 ,移植肿瘤后 5d ,A组 (n =8)接受假照治疗 ;B组 (n =12 )接受HIU治疗 ;C组 (n =8)接受手术治疗。从B组中任选 4只兔于治疗后 2d处死 ,对靶区进行病理学检查。在HIU治疗过程中 ,测量靶区组织温度变化。检查兔肝肾功能 ,记录兔生存时间。结果 靶区组织发生坏死 ,靶区外的组织不受损伤。靶区温度达 85℃ ,靶区外 0 .5mm处仅升高 2℃。A、B、C 3组中位生存时间分别为 5 4、15 0、15 0d ;治愈率为 0、75 .0、6 2 .5 ;B、C两组较A组生存时间明显延长 (P <0 .0 5 ) ;B、C两组间生存时间和治愈率差异无显著性 (P >0 .0 5 )。结论 HIU能较有效安全地治疗早期兔肝VX2

Objective To investigate the efficacy and security of high intensity ultrasound (HIU) in the treatment of early stage rabbit VX 2 cancer implanted in the liver. Methods Twenty eight rabbits with liver tumors were randomly divided into three groups five days after implantation: group A ( n =8) did not receive therapy; group B ( n =12) received HIU sonication; group C ( n =8) received operation therapy.In the group B, at random, 4 of 12 was sacrificed on the 3rd day after ultrasound exposure to assess pathological changes of targeted tissue under light microscopy. During the HIU therapy, the temperature changes of targeted tissue were recorded. The survival time of each rabbit was recorded. Liver and renal functions were examined at predetermined times. Results Targeted tissue showed an irreversible death following treatment and the hepatic parenchyma outside the targeted tissue was normal. During HIU therapy,the temperature of the targeted tissue rose to 85℃, but the tissue's temperature 0.5 mm outside the target only raised 2℃. The survival time of rabbits in each group was 54d in group A, 150 d in group B, 150 d in group C, and their cure rate was 0(0/8), 75.0(6/8), 62.5 (5/8) respectively. Compared with group A, the survival in the group B and group C was significantly longer( P < 0.05 ). However, there were no significant differences in survival time or tumor cured rate between group B and group C. Conclusion HIU can effectively and safely treat rabbit VX 2 cancer implanted in liver. [