升白汤对肿瘤化疗所致白细胞减少的防治作用

The clinical effective observation of ShengBaiTang on treating leukopenia caused by cancer chemotherapy

目的：观察升白汤对肿瘤化疗所致白细胞减少的防治作用。方法：采用随机分组自身交叉对比法，将36例患者分为A、B两组，A组第一周期化疗后予升白汤及鲨肝醇、利血生，第二周期仅服西药；B组第一、第二周期给药分别与A组第二、第一周期给药相同。结果：A、B两组两周期化疗后升白汤治疗组WBC分别比西药对照组增加(1.07±0.94)×109/L(Ｐ＜0.001)和(0.88±0.21)×109/L(Ｐ＜0.001)；WBC＜4.0×109/L持续时间分别比西药对照组缩短12.31±6.45天(Ｐ＜0.001)和13.17±7.58天(Ｐ＜0.001)。两组升白汤治疗周期的感染例数少于西药对照周期(Ｐ＜0.05)。结论：升白汤配合鲨肝醇、利血生口服可作为肿瘤化疗期间白细胞减少症的有效防治方法。

Objective:To observe clinical effect of Shen gBaiTang on treating leukopenia caused by cancer chemotherapy.Methods:Thirty－six cases were divided into two groups by a randomiz ed cross over trial,each patient in group A received one cycle of chemotherapy f ollowed ShengBaiTang,batilol and leucogen,another cycle gave batilol and leucogen;for eac h patient in group B,the treatment of 2 cycles of chemotherapy followed was cont ray to that in group A.Chemotherapeutic drugs and dosage were identical in 2 cy cles for each patient in two groups.The change of absolute leucocyte count durin g chemotherapy between the 2 cycles was compared.Results:After chemotherapy,the white blood cell(WBC) was increased( 1.07±0.94)×109/L、(0.88±0.21)×109/L(Ｐ＜0.001)，respectively and the time of WBC lasting less than 4.0×109/L was shortened by 12.31±6.45 days and 13.17±7.58 days(Ｐ＜0.001),respectively between one cycle treated by ShengBaiTang and another cycle treated by westen medicine in group A and B.The infected patients were less during ShengBaiTang treating cycle than another cycle in two groups(Ｐ＜0.05) respecti vely.Conclusions:Oral administration of ShengBaiTang and batilol,leucogen can play an important role in treating leukopenia cau sed by cancer chemotherapy.