甘油氯化钠注射液降低颅内压52例临床观察

Clinic observation of glycerol and sodium chloride injection reducing intracranial pressure：A report of 52 cases

目的：评价甘油氯化钠注射液降低颅内压的临床效果以及观察有无副作用。方法：对52例颅内压增高患者用甘油氯化钠降低颅内压，与44例用甘油果糖及32例用甘露醇降低颅内压进行比较，通过颅内压监测仪观察效果及副作用。结果：注射甘油氯化钠后1.05±0.23 h颅内压开始下降，2.32±0.36 h作用达到高峰，持续5.25±1.42 h；无反跳现象，对肾功能影响小，无溶血现象。结论：甘油氯化钠注射液适用于亚急性颅内压增高、高龄患者及肾功能有损害者。

Objective:To observe the clinical effect of glycerol and sodium chloride injection on intracranial pressure reduction and it s side effects.Methods:To reduce the intracranial pressure,we used glycerol and sodium chloride injection in 52 cases of intracranial hypertension,glycerol and fructose infusion in 44 cases and 20% mannitol in 32 cases respectivel y and to observe the effects a nd side effects by intracranial pressure monitoring instrument.Results:After glycerol and sodium chloride injection was used 1.05± 0.23 hours,intracranial pressure began to reduce.The maximum of effect was achieved 2.32±0.36 hours after injection and lasted for 5.25±1.42 hours.No rebound or haemolysis occured and it had little influence on renal function.Conclusions:Glycerol and sodium chloride injection can be used in pa tients with subacute intracranial hypertension,older patients and patients with renal damage.