脐动脉多普勒血流测定在肝内胆汁淤积症的应用

Application of umbilical arterial blood flow measurement with color ultrasound doppler's method in intrahepatic cholestasis during pregnancy

目的：评价脐动脉多普勒血流测定(S/D)与无负荷试验(NST)在妊娠期肝内胆汁淤积症(ICP)中的应用价值。方法：应用S/D与NST对孕龄为35～40周157例ICP患者进行动态监测，并对新生儿Apgar评分和羊水粪染的情况进行比较。结果：脐动脉血流S/D＜3、NST≥7分，胎儿预后良好；脐动脉血流S/D≥3、NST＜7分，胎儿预后不佳，两者差异有显著性(Ｐ＜0.005)。结论：脐动脉多普勒血流检测弥补单纯NST对ICP患者胎儿预后判断的不足，提高临床诊断准确率。

Objective:To estimate the value of combining fetal umbilical arterial blood flow measurement with nonstress test(NST) in pat ients with intrahepatic cholestasis during pregnancy(ICP). Methods:The systolic/diastolic(S/D) ratio combined with NST of 157 p atients with ICP whose gestational ages were from 35 to 40 weeks were studied by using umbilical artery velocity waveform and they were compared with Apgar score and amniotic fluid condition. Results:Compared the abnormal S/D≥3 and NST＜7 with and normal S/D＜3 and NST≥7 in ICP,there was a significant higher incidence of fetal distress(Ｐ＜0.005). Conclusions:These data suggest that combined umbilical artery velocity S/D ratio with NST can increase diagnostic reliability of fetal distress in patients with ICP,and it is important in foreseen prognosis of ICP fetus.