欣可聆预防妇产科手术后盆腹腔粘连的临床研究

Clinical value of singclean used in the prevention of intraperitoneal adhesion after obstetrics and gynecology operation

目的探讨防粘连制剂——欣可聆（Singclean，医用透明质酸钠凝胶）在妇产科手术中的防粘连效果及其临床应用价值。方法2011年10月~2013年6月在深圳市第二人民医院妇产科因各种妇科疾病接受手术的病例共1000例分为：子宫肌瘤手术组300例，卵巢子宫内膜异位囊肿手术组300例，卵巢非子宫内膜异位囊肿手术组200例，剖宫产手术组200例术。以上每组按照4：1的比率分为试验组和对照组。试验组生理盐水冲洗腹腔后用欣可聆覆盖创面，对照组仅用生理盐水冲洗腹腔。术后定期随访，判断是否有盆腹腔粘连发生。结果各试验组盆腹腔粘连发生率均低于对照组，且差异均无显著性（P〈0．005）。结论欣可聆能有效预防妇产科术后盆腹腔粘连的产生。

[ Objective ] To investigate the effect of Singclean in the prevention of the intraperitoneal adhesions after the obstetrics and gynecology operation. [Methods] A total of 1 000 patients undergoing obstetrics and gynecology operation in the author＇s hospital were divided into four groups： 300 cases of the uterine myoma group, 300 cases of the ovarian endometriosis group, 200 cases of the ovarian cyst （eliminate ovarian endometriosis） group and 200 cases of cesarean section group. According to the proportion of 4：1, each group was divided into two groups： the experimental group and the control group. In the experimental group Singclean （the sodium hyaluronate gel） was used to cover the traumas after using the normal saline to wash the peritoneal cavity. While in the control group only he normal saline were simply used to wash the peritoneal cavity. All patients were followed up regularly after operation and tested the appearance of adhesions. [Results ] The incidence of intraperitoneal adhesions in the experimental group was significantly lower than that in the control group （P 〈0.05）. [ Conclusion ] Singclean （the sodium hyaluronate gel） can effectively prevent the intraperitoneal adhesions after the obstetrics and gynecology operation.operation.