摘要
目的初步探索99mTc-明胶作为肾小球滤过性肾功能显像剂的可能性。方法运用99Mo-99mTc发生器制备99mTc-明胶,测定99mTc-明胶在心、肝、肺、脾、肾、胃等器官的放射性计数,计算每单位质量组织放射性摄取率。结果 99mTc-明胶有比较高的肾摄取率,同时有较长的滞留时间,在血液中的清除也很快。结论 99mTc-明胶有可能成为一种肾小球滤过型肾功能显像剂。
Objective To explore the possibility of 99mTc-gelatin acting as imaging reagent for glomerular filtration. Methods 99mTc-gelatin was prepared by using 99Mo-99mTc generator. Rate of Radioactive uptake and radiocounting of 99mTc-gelatin were detected in heart,liver,lung,spleen,kidney and stomach of mice. Results High uptake rate and long holding period of 99mTc-gelatin were discovered in kidney,but the removal in blood was very fast. Conclusion 99mTc-gelat-in was hopeful to be a kind of imaging reagent of glomerular filtration.
出处
《中国辐射卫生》
2013年第6期661-662,共2页
Chinese Journal of Radiological Health
基金
国家自然科学基金资助项目(31200634
31170804
31240052)
天津市自然科学基金(11ZCGYSY02400
12JCYBJC15300
12JCYBJC32900)
协和青年基金资助
中央高校基本科研业务费专项资金资助(2012J05
2012G01)
中国医学科学院放射医学研究所学科发展基金(1307
1308
1310
1338
1335)
关键词
99mTc
明胶
生物学分布
显像剂
99mTc
Gelatin
Biological Distribution
Imaging Reagent
