旱莲草化学成分的研究

STUDIES ON THE CHEMICAL CONSTITUENTS OF ECLIPTA PROSTRATA (L)

目的 研究常用中药旱莲草 (EcliptaprostrataL)的化学成分。方法 采用Bohlmann法和渗漉热提法以及色谱法对旱莲草化学成分进行分离纯化 ,用波谱法对其结构进行鉴定。结果 从旱莲草脂溶性部位及亲水性部位分得 10个化学成分 ,分别确定为蟛蜞菊内酯 (1) ,去甲蟛蜞菊内酯 (2 ) ,异去甲蟛蜞菊内酯 (3) ,α 醛基三聚噻吩(4 ) ,吕宋果内酯 (5 ) ,β 谷甾醇 (6 ) ,正二十九醇 (7) ,硬脂酸 (8) ,三十二碳酸 (9) ,龙胆酸 (10 )。脂溶性部位的极性最小部位通过气质联用方法进行检测 ,鉴定出 14个脂肪烃以及脂肪酸酯类化学成分。结论 化合物 3为新化合物 ,2- 10及通过GC MS鉴定的 14个化合物均为首次从旱莲草中分得和检出。

AIM To study the chemical constituents of Eclipta prostrata (L). METHODS The constituents of E.prostrata were systematically separated with the Bohlmann method and percolation and hot extraction methods, and various chromatographies. The structures were elucidated by chemical and spectroscopic means. RESULTS Ten compounds were isolated from the Eclipta prostrata . Their structures were determined as wedelolactone (1), demethylwedelolactone (2), isodemethylwedelolactone (3), α formylterthienyl (4), strychnolactone (5), β sitosterol (6), nonacosanol (7), stearic acid (8), lacceroic acid (9), 3,4 dihydoxy benzoic acid (10). Fourteen ocmpounds, including hydrocarbons and its esters were identified by GC MS from the least polar fractions. CONCLUSION Compound 3 is a new coumestan named isodemethylwedelolactone. Compounds 2-10 and compounds characterized by GC MS analysis were obtained for the first time from Eclipta prostrata .