毛萼梅根化学成分研究

CHEMICAL CONSTITUENTS FROM THE ROOT OF RUBUS CHROOSEPALUS

目的 研究毛萼梅根部的化学成分。方法 将MeOH提取物分散于水中 ,经EtOAc萃取后用柱色谱分离纯化 ,通过波谱方法鉴定化合物。结果 鉴定了 7个化合物 :2α ,3β 二羟基乌苏 12 ,19 二烯 2 3 ,2 8 二酸 (I) ,2α,3β ,2 3 三羟基乌苏 12 ,18 二烯 2 8 酸 (IIa) ,2α ,3β ,2 3 三羟基乌苏 12 ,19 二烯 2 8 酸 (IIb) ,2α ,3α 二羟基乌苏 12 ,18 二烯 2 8 酸 (IIIa) ,2α,3α 二羟基乌苏 12 ,19 二烯 2 8 酸 (IIIb) ,及化合物IIIa ,IIIb的C 2 ,C 3位缩酮IVa和IVb。结论 I是 1个新三萜酸。

AIM To investigate the chemical constituents of Rubus chroosepalus Focke. METHODS The methanol extracts were suspended in H 2O and then extracted with EtOAc. Column chromatography was used for separation and purification, while spectral analysis was used for identification. RESULTS Seven compounds were isolated and identified as 2α,3β dihydroxy urs 12,19 dien 23,28 oic acid (I), 2α,3β,23 trihydroxy urs 12,18 dien 28 oic acid (IIa), 2α,3β,23 trihydroxy urs 12,19 dien 28 oic acid (IIb), 2α,3α dihydroxy urs 12,18 dien 28 oic acid (IIIa), 2α,3α dihydroxy urs 12,19 dien 28 oic acid (IIIb), and the acetonide of IIIa and IIIb (IVa and IVb). CONCLUSION I was found to be a new pentacyclic triterpenoid acid.