摘要
KL-6为肿瘤分化抗原,是一种跨膜高分子量的黏蛋白.近年来研究发现某些疾病,如间质性肺疾病、急性肺损伤、肿瘤及早产儿支气管肺发育不良等,患者血清及支气管肺泡灌洗液中KL-6水平不同程度的升高,因此建议把KL-6作为间质性肺疾病和肿瘤的临床早期诊断、疗效评价和转归评估的参考指标,但有关KL-6在不同疾病进程中的分子生物学机制尚有待于进一步研究.
Krebs von den Lungen-6（KL-6） is a high-molecular-weight transmembrane mucin.In recent research,the levels of KL-6 in serum and bronchoalveolar lavage fluid are significantly higher in some pulmonary disease such as interstitial lung disease,acute lung injury,tumor and bronchopulmonary dysplasia.Consequently KL-6 is recommended as a reference index for early diagnosis,evaluation of therapeutic efficiency and outcome prediction.But the molecular mechanism of KL-6 in different diseases requires further research.
出处
《国际儿科学杂志》
2013年第6期565-568,共4页
International Journal of Pediatrics
基金
国家自然科学基金资助（编号81170605
30872781）
