婴儿组织胞浆菌病1例并文献复习

A infant case of histoplasmosis and relevant literature review

目的提高对婴儿组织胞浆菌病(histoplasmosis,HP)的认识。方法报告1例婴儿组织胞浆菌病,并结合文献对该病病原学、流行病学、临床表现、诊断和治疗等方面进行分析。结果婴儿HP以不规则发热、咳嗽、腹泻、肝脾肿大为主要临床表现,骨髓穿刺检查找到组织胞浆菌确诊。结论 HP是由荚膜组织胞浆菌感染所致的一种以侵犯网状内皮系统或肺部为主的深部真菌病。婴儿HP临床表现多样,以播散型为主,病情进展迅速,在短期内即可造成多器官功能衰竭而导致救治失败。确诊有赖病原学的检查。

Objective To improve awareness on infant histoplasmosis （HP）. Methods This study reports 1 infant of histoplasmosis and discusses it combined with the literature on the disease etiology, epidemiology, clinical manifestations, diagnosis and treatment. Results Infants with HP was of irregular fever, cough, diarrhea, hepatosplenomegaly as the main clinical manifestations; a bone marrow puncture examination can confirm histoplasmosis. Conclusion HP is a histoplasma pyriforme infection invading the reticuloendothelial system or the lung mainly so developing deep mycosis. Infant＇ s clinical manifestations of HP are various, and predominant by disseminated; the condition has rapid progress so that in the short term can cause multiple organ failure leading to treatment failure. The disease could be confirmed depending on the inspec- tion of etiology.