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hs-CRP与BNP检测在心源性哮喘与肺源性哮喘鉴别诊断中的意义 被引量:5

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摘要 目的探讨超敏C反应蛋白(hs-CRP)、B型尿钠肽(BNP)在心源性哮喘与肺源性哮喘鉴别诊断中的意义。方法选取该院收治的以呼吸困难为主要症状的患者144例,其中心源性哮喘患者66例,肺源性哮喘患者78例,另选择同期门诊体检健康者30例作为对照组。测定3组1s用力呼气容积(FEV1)、用力肺活量(FVC)、血浆hs-CRP、BNP。结果 (1)心源性哮喘组和肺源性哮喘组血浆hs-CRP、BNP均明显高于对照组,FEV1%和FEV1/FVC明显低于对照组(P<0.01);心源性哮喘组血浆hs-CRP明显低于肺源性哮喘组,血浆BNP明显高于肺源性哮喘组(P<0.01)。(2)心源性哮喘组中患者心功能越差,血浆BNP水平越高,各组患者血浆BNP水平比较有统计学差异(P<0.05);NYHAⅡ级和NYHAⅢ级血浆hs-CRP比较,差异无统计学意义(P>0.05)。(3)肺源性哮喘组中患者呼吸功能越差,血浆hs-CRP水平越高,不同呼吸功能患者血浆hs-CRP不同(P<0.05)。(4)以BNP>200pg/mL作为阳性诊断临界值,其对心源性哮喘和肺源性哮喘的诊断敏感度为95.45%,特异度为76.92%,阳性预测值为77.80%,阴性预测值为95.24%,准确率为85.42%。结论血浆hs-CRP和BNP检测对心源性哮喘与肺源性哮喘有积极意义,两种指标检测方便,值得临床推广应用。
作者 乐永宏
出处 《重庆医学》 CAS CSCD 北大核心 2013年第33期4084-4085,共2页 Chongqing medicine
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