热毒宁注射液辅助治疗重度AECOPD患者前后血液中CRP、PCT和TNF-α水平的变化

Reduning injection reduces serum levels of CRP,PCT and TNF-αin Patients with severe acute exacerbation of chronic obstructive pulmonary disease

目的探讨热毒宁注射液辅助治疗重度慢性阻塞性肺疾病急性加重期(AECOPD)患者前后血液中CRP、PCT和TNF-α水平的变化。方法 100例重度AECOPD患者(D级)随机平均分为热毒宁+常规治疗组(干预组)和常规治疗组(对照组),分别测定0天和3天时患者动脉血气指标(pH、PO2和PCO2),FEV1占预计值%,血浆CRP、PCT和TNF-α水平。结果经3天治疗后两组患者动脉血气指标(pH、PO2和PCO2),FEV1占预计值%,血浆CRP、PCT和TNF-α水平均明显改善;同时与对照组相比较,干预组动脉血气指标(pH、PO2和PCO2)和FEV1占预计值%未见明显差异(均P>0.05),但血浆CRP、PCT和TNF-α水平下降更明显(均P<0.05)。同时该实验过程中干预组患者未出现与热毒宁注射液相关的严重不良反应。结论热毒宁可以有效减少重度AECOPD(D级)患者血浆CRP、PCT和TNF-α水平,为热毒宁应用于COPD的临床治疗奠定了理论基础。

Objective To investigate the value of Reduning injection on serum levels of CRP,PCT and TNF-α in patients with severe AECOPD （grade D）.Methods One hundred of patients with severe AECOPD （grade D） were randomly divided into two groups,regular treatment group （control group） and reduning＋ regular treatment group （intervention group）,with 50 cases in each group.Arterial blood gas （ABG） indexes,FEV1%,the serum levels of CRP,PCT and TNF-α were measured before and after 3 days treatment.Results After 3 days treatment,ABG indexes （pH,PO2 and PCO2）,FEV1 %,the serum levels of CRP,PCT and TNF-αwere all improved in both two groups （P〈0.05 in all）.However,no difference on ABG indexes （pH,PO2 and PCO2） and FEV1 % was found between two groups （P〉0.05 in all）.Nevertheless,the serum levels of CRP,PCT and TNF-α in intervention group were significantly lower than in control group （P〈0.05 in all）.Meanwhile,no severe side effect has been found in this study.Conclusion Our results demonstrated that Reduning injection may be an effective drug in AECOPD treatment by inhibition of inflammatory reaction though inactivation of NF-κB.However,more multiple center and wild scale studies should be applied to identify the value of Reduning injection in the treatment of COPD.