降钙素原和超敏C反应蛋白检测在再生障碍性贫血合并肺部感染患者病原菌诊断中的意义

Significance of procalcitonin and hypersensitive C-reactive protein detection in pathogens diagnosis of patients with aplastic anemia and pulmonary infection

目的探讨降钙素原(PCT)和超敏C反应蛋白(hs-CRP)在再生障碍性贫血合并肺部感染患者病原菌诊断中的意义。方法将98例再生障碍性贫血合并肺部感染患者分为细菌感染组(n=28)、真菌感染组(n=28)、细菌合并真菌感染组(n=28)、支原体或病毒感染(n=14),并以健康体检者作为对照组(n=28)。检测各组患者降钙素原(PCT)和超敏C反应蛋白(hsCRP)及WBC。结果与对照组比较,细菌感染组、真菌感染组、细菌合并真菌感染组患者PCT和hs-CRP均有不同程度升高,而支原体或病毒感染组的变化不明显。各感染组患者WBC明显低于对照组(P<0.01)。与单纯真菌感染相比,革兰阳性菌和革兰阴性菌感染患者的PCT和hs-CRP均有不同程度升高,差异有统计学意义(P<0.05)。与总体真菌感染患者比较,念珠菌感染患者PCT值高于曲霉菌感染(P<0.05)。结论 PCT和hs-CRP检测对再生障碍性贫血合并肺部感染患者的病原菌诊断具有重要意义。

Objective To discuss the significance of procalcitonin（PCT） and hypersensitive C-reactive protein（hs-CRP） detec- tion in pathogens diagnosis of patients with aplastic anemia and pulmonary infection.Methods 98 patients with aplastic anemia and pulmonary infection were divided into bacterial infection group（n=28）,fungal infection group（n=28）,bacterial and fungal infection group（n=28）,mycoplasma or viral infection group（n=14）,and healthy individuals were served as a control group（n=28）.Procal- citonin（PCT,hypersensitive C-reactive protein（hs-CRP）and WBC of patients in each group were detected.Results Compared with control group,PCT and hs-CRP of patients in bacterial infection group,fungal infection group,bacterial and fungal infections group increased in varying degrees,while changes of those in mycoplasma or viral infection group were not significant.WBC in infection groups were significantly lower than that in control group（P〈0.01）.Compared with fungal infections,PCT and hs-CRP of patients with gram-positive bacteria and gram-negative bacterial infection increased in varying degrees,with statistically significant differece（P〈0.05）.Compared with patients with general fungal infections,PCT of patients with Candidainfection was higher than than that of patients with Aspergillus infection（P〈0.05）.Conclusion PCT and hs-CRP tests shows important significance for patho- gen diagnosis of patients with aplastic anemia and pulmonary infection.