念珠菌抗原金标法检测聚维酮碘辅助治疗外阴阴道假丝酵母菌病效果的临床价值

Clinical value of gold labeled immunochromatographic assay in detecting the effects of povidone iodine on adjuvant treatment for vulvovaginal candidiasis

目的探讨金标免疫层析检测技术(GICA)检测聚维酮碘辅助治疗外阴阴道假丝酵母菌病的临床价值。方法将96例VVC患者分为治疗组(n=48)和对照组(n=48)。治疗组患者予氟康唑口服、硝呋太尔制霉菌素及聚维酮碘外用;对照组患者予氟康唑口服、硝呋太尔制霉菌素阴道软胶囊外用,而不用聚维酮碘。采用GICA比较2组的治疗效果。结果 GICA较显微镜检查及临床症状评价有较高的符合率。治疗组和对照组患者的总有效率分别为97.92%、91.66%,复发率分别为4.16%、20.83%,二者差异均有统计学意义(P<0.05)。结论聚维酮碘在VVC治疗中具有较好的辅助治疗作用,GICA较显微镜检查更为准确。

Objective To investigate the value of gold labeled immunochromatographic assay（GICA） in adjuvant treatment of povidone iodine for vulvovaginal candidiasis.Methods 96 patients with VVC were divided into treatment group（n=48） and control group（n=48）.Patients in treatment group were administered fluconazole orally,and nystatin nifuratel and povidone iodine for topi- cal application.Patients in control group were administered fluconazole orally and nystatin nifuratel for topical application,without povidone iodine.GICA was employed to compare the therapeutic effects between the two groups.Results Coincidence rate of GICA was higher than these of microscopic examination and evaluation of clinical symptom.The total effective rates of patients in treat- ment group and control group were 97.92%,91.66%,respectively,and their recurrence rates were 4.16%,20.83%,respectively, with statistically significant differences（P〈0.05）.Conclusion Povidone-iodine may have better adjuvant effect in VVC treatment and GICA is more accurate than microscopy.