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血小板活化指标在急性脑梗死疾病中的应用研究 被引量:6

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摘要 目的探讨急性脑梗死患者脑梗死初期发生时血小板活化指标的变化规律。方法将115例急性脑梗死患者作为脑梗死组,30例该院同期体检健康者作为对照组。检测其血浆CD62P、溶血磷脂酸(LPA)及LPA相似磷脂水平。结果脑梗死组患者在发病24h内,CD62P、LPA、LPA相似磷脂浓度均显著高于对照组,差异有统计学意义(P<0.01)。CD62P、LPA、LPA相似磷脂在ROC曲线下的面积:CD62P为0.95,LPA相似磷脂为0.969,LPA为0.972。根据ROC曲线,当CD62P临界值为26.78%时,诊断的敏感性为88%,特异性为87%;LPA相似磷脂临界值为5.32μmol/L时,诊断的敏感性为93%,特异性为93%;LPA临界值为3.12μmol/L时,诊断的敏感性为94%,特异性为94%。脑梗死组患者CD62P、LPA、LPA相似磷脂的相关分析显示,CD62P与LPA相似磷脂(r=0.221 9,P>0.01),CD62P与LPA(r=0.260 2,P>0.01)无明显相关性;LPA与LPA相似磷脂(r=0.856 7,P<0.01)呈显著正相关。结论急性脑梗死患者初期血小板活化明显,血小板活化指标CD62P、LPA、LPA相似磷脂可作为急性脑梗死发生初期诊断的辅助指标。
出处 《国际检验医学杂志》 CAS 2013年第23期3232-3234,共3页 International Journal of Laboratory Medicine
基金 江苏省中医药管理局课题(HLZ09028)
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参考文献12

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