纳洛酮用于慢性呼吸衰竭并肺性脑病的临床观察

The Clinical Observation of Naloxone in Treatment of Chronic Respiratory Failure and Pulmonary Encephalopathy

目的:对纳洛酮治疗慢性呼吸衰竭并肺性脑病的临床效果进行分析和观察。方法:以本院2009年1月-2012年1月收治的60例慢性呼吸衰竭并发肺性脑病患者为研究对象,采用随机分配的原则将所有患者分成对照组和试验组各30例。对照组患者采用常规的治疗措施,试验组患者则在常规治疗措施的基础上,增加纳洛酮进行治疗。对两组患者的血气分析、清醒时间以及临床效果进行观察和比较。结果:两组患者在血气分析上均有效改善。治疗后,两组患者的PaO2以及PaCO2均有明显变化,PaO2显著升高,PaCO2显著下降,两组治疗前后比较差异均有统计学意义(P<0.05);试验组清醒时间明显短于对照组患者,两组比较差异有统计学意义(P<0.05)。试验组的总有效率明显高于对照组,两组比较差异有统计学意义(P<0.05)。结论:对慢性呼吸衰竭并发肺性脑病患者使用纳洛酮进行治疗,能够有效帮助患者恢复神志,有利于肺通气的改善,具有较高的临床应用价值,值得推广和普及。

Objective：To analyze and observe the clinical effect of the naloxone in the treatment of chronic respiratory failure and pulmonary encephalopathy. Method：The clinical study mainly by the hospital from January 2009 to January 2012 were analyzed in 60 cases of chronic respiratory failure complicated by pulmonary encephalopathy patients as the research object,based on the principle of random distribution,patients were divided into the control group and the experimental group,each group of 30 cases. The control group was treated by routine treatment,the experimental group patients on the basis of routine treatment,increasing treated with naloxone. On two groups of patients with blood gas analysis,awaked time and clinical effect were observed and compared.Result：All patients of PaO2 and PaCO2 were changed significantly. PaO2 was significant increasing and PaCO2 was significant decreasing,and the difference of before and after treatment between the two groups were all statistically significant（P〈0.05）. The awaked time of the experimental group was significantly shorter than the control group（P〈0.05）and clinical effect rate of the experimental group was significantly better than the control group（P〈0.05）.Conclusion：For patients with chronic respiratory failure complicated by pulmonary encephalopathy treated with naloxone, can effectively help patients recover consciousness,is beneficial to the improvement of pulmonary ventilation,is of high clinical application value,worthy of promotion and popularization.