血小板单核细胞聚集体对全麻手术患者血小板活化状态观察的重要性

The Importance of the Presentation of PMA in Evaluating the Platelet Activation in Patients with General Anesthesia

目的:观察血小板单核细胞聚集体(PMA)在全麻手术前后及术后3 d的变化,了解检测PMA对全麻手术前后血栓形成预测的意义。方法:流式细胞术检测112例全麻手术患者手术前、手术后及手术后3 d CD62p、CD63、PMA的表达,比较其在3个不同时间的差异。结果:112例患者麻醉诱导前、手术后、术后3 d CD62p的表达分别为(16.74±9.67)%、(22.76±13.89)%、(20.12±9.83)%;CD63的表达分别为(1.35±0.94)%、(2.26±1.75)%、(1.54±0.81)%;PMA的表达分别为(26.86±5.05)%、(31.86±5.31)%、(77.69±5.72)%;手术后CD62p、CD63、PMA,术后3 d CD62p、PMA与麻醉诱导前比较差异均有统计学意义(P<0.05)。结论:PMA可以作为评价血小板活化的指标,并且是一种敏感指标,可能在预测血栓形成中有重要意义。

Objective：To predict the risk of thrombosis in patients with surgery under general anesthesia by monitoring the platelet-monocyte aggregates（PMA）level before the general anesthesia,immediately after the surgery and 3 days after the surgery. Method：Blood samples were collected from 112 cases of patients with surgery under the general anesthesia before the general anesthesia,immediately after the surgery and 3 days after the surgery. The presentation of CD62p,CD63 and PMA were measured and compared. Result：The presentation of CD62p before the general anesthesia,immediately after the surgery and 3 days after the surgery were（16.74±9.67）%,（22.76±13.89）%,（20.12±9.83）%. The presentation of CD63 were（1.35±0.94）%,（2.26±1.75）%,（1.54±0.81）%,and the presentation of PMA were（26.86±5.05）%,（31.86±5.31）%、（77.69±5.72）%;The presentation of CD62p,CD63 and PMA immediately after surgery and the presentation of CD62p,and PMA 3 days after the surgery compared with before the general anesthesia,the differences were all statistically significant（P〈0.05）. Conclusion：PMA is a sensitive biomarker to evaluate the degree of platelet activation and to predict the possible postoperative thrombosis.