深圳市坪山新区婴幼儿肺炎克雷伯杆菌对药物敏感性分析

Sensitivity of Drugs on Klebsiella Pneumonia Isolated from Children in Shenzhen Pingshan New District Maternity and Child Care Hospital

目的:对深圳坪山新区婴幼儿的肺炎克雷伯菌(Kp)药敏结果进行回顾性分析。方法:回顾性分析从儿童送检的痰标本中分离非重复的Kp121株,观察肺炎克雷伯菌药敏结果,监测其耐药谱。结果:肺炎克雷伯菌对氨苄西林和哌拉西林的耐药率高达91.7%,而对肺炎克雷伯菌敏感率高达90%的药物分别为阿米卡星(100%)、泰能(96.7%)、左氧氟沙星(95.9%)、加替沙星(95.9%)、环丙沙星(95.9%)。结论:循环使用抗生素、使用低耐药诱导药替代高耐药诱导药及定期监测耐药谱,对婴幼儿患者避免耐药菌的感染有着重要作用。

Objective： To retrospectively analyzed pneumonia isolated from the children in Shenzhen Pingshan new district maternity and child care hospital. Method： One hundred and twenty-one klebsiella pneumonia isolated from the children were sent for susceptibility testing. Then, the activities of antibacterial agents against klebsiella pneumonia were analyzed. Result： The authors found that the drug-resistance rate of ampicillin and piperacillin were as high as 91.4%. The activity of antibacterial agents against klebsiella pneumonia were as follows： Amikacin （ susceptible rate, 100% ）, Imipenem （ 96.7% ）, Levofloxacin （ 95.9% ）, Gatifloxacin （ 95.6% ） and Ciprofloxacin （ 95.6% ） . Conclusion： The changes of resistance should be monitored dynamicly, and these high resistance-inducing drugs should be replaced by low resistance-inducing drugs. Drugs should be circulation used in order to reduce the risk of infection of resistant Klebsiella pneumonia for the children.