女性不孕症的环境影响因素的研究

Study on environmental and psychological risk factors for female infertility

目的探索女性不孕的环境和心理影响因素，为女性不孕症的预防和控制提供科学依据。方法采用医院为基础的1：1配对的病例对照研究，自制调查问卷进行问卷调查，每个病例配一个对照，配比变量为民族和年龄（±2岁）。利用单因素和多因素的条件logistic回归分析结果。结果单因素分析发现，女性不孕与食用煎炸食品、饮酒、吸烟、熬夜、烫发、住房装修、接触重金属、接触放射线、接触农药、高温作业、精神压力、心里不安、无助失望有关。多因素分析显示：熬夜（OR=2．937）、住房装修（OR=2．963）、接触放射线（OR=2．506）、接触农药（OR=2．908）以及精神压力（OR=4．101）是主要环境影响因素，且熬夜和精神压力存在交互作用。结论女性不孕症与熬夜、住房装修、接触放射线、接触农药以及精神压力等因素有关，熬夜和精神压力存在交互作用。

Objective To investigate the environmental and psychological risk factors for female infertility and to provide a scientific basis for the prevention and control of female infertility. Methods In a hospital-based case-control study, a self-designed questionnaire was used to survey the cases and controls （1：1 ） with nation and age （＋2 years） as matching variables. Univariate and multivariate conditional logistic regression models were employed to analyze the datasets. Results The univariate analysis showed that female infertility was related to the following factors： eating fried foods, alcohol consumption, smoking, staying up late, penn, housing decoration, contact with heavy metals, exposure to radiation, contact with pesticides, working in hot environment, mental stress, uneasiness, helplessness, and despair. The multivariate analysis showed that staying up late （OR=2.937）, housing decoration （OR=2.963）, exposure to radiation （OR=2.506）, contact with pesticides （OR=2.908）, and mental stress （OR=4.101） were the main risk factors for female infertility. Furthermore, there was an interaction between staying up late and mental stress. Conclusion Female infertility is caused by multiple factors including staying up late, housing decoration, exposure to radiation, contact with pesticides, and mental stress, and there is an interaction between staying up late and mental stress.