糖尿病患者胃癌发病风险增加的荟萃分析

Diabetes mellitus increases the risk of gastric cancer: A meta-analysis

目的:探索糖尿病与胃癌的发生的病因学联系.方法:检索美国一项索引(MedLine)、荷兰医学文摘(EMBASE)、Cochrane图书馆和中国生物医学文献数据库(1990-01/2013-07)国内外公开发表的关于糖尿病患者的胃癌发病率的前瞻性队列研究,共有15项研究符合纳入标准.我们以NOS评定量表(Newcastle-Ottawa Quality Assessment Scale)为依据进行质量评价,使用STATA12.0软件,选用DerSimonianLaird的随机效应模型.结果:与对照组相比,糖尿病患者经Meta分析后的发生胃癌的相对危险度(relative risk,RR)值为1.15,95%CI:1.11-1.19,提示糖尿病患者胃癌发病风险增加.结论:糖尿病患者的胃癌发病风险增加.

AIM： To systematically assess the association between diabetes mellitus and the risk of gastric cancer METHODS： We searched Medline （PubMed）, EMBASE, the Cochrane Library and CBN data- bases from January 1990 to July 2013. We also searched the references of qualifying articles. Cohort studies comparing the risk of gastric cancer between diabetic patients and control subjects were included. Fifteen studies met our criteria, and the quality of these studies was assessed using the Newcastle-Ottawa Quality Assessment Scale. Meta-analysis was performed using the random-effects model （DerSimonian- Laird method）. RESULTS： The meta-analysis showed an in- creased gastric cancer risk in diabetic patients [relative risk （RR） = 1.15, 95%CI： 1.11-1.19]. CONCLUSION： Diabetes mellitus may increasethe risk of gastric cancer.