北京及广州地区汉族男性儿童青少年手腕骨骨龄的差异分析

The analysis of variation of Han male children and adolescent bone age of wrist-hand in Beijing and Guangzhou

目的 探讨北京及广州地区汉族男性儿童青少年手腕骨骨龄的差异.方法 对照CHN标准骨龄图谱,回顾性分析北京、广州两地1.0～19.0岁正常汉族男性儿童青少年左手腕部X线片993例（其中北京617例,广州376例）,盲法评测骨龄.评估观察者读片一致性;采用配对t检验评估分析骨龄和实际年龄的差异;采用独立样本t检验,比较北京、广州两地骨龄与实际年龄的差值,评估两者差异.结果 使用CHN图谱法评估的北京、广州两地汉族男性儿童青少年手腕骨骨龄与实际年龄高度相关（r值分别为0.969、0.957,P值均＜0.01）;北京在1.0～3.9、7.0～15.9岁12个年龄段骨龄高于实际年龄,广州在1.0 ～2.9、6.0～7.9岁4个年龄段骨龄高于实际年龄;两地区间骨龄与实际年龄差值比较,在1.0～1.9、9.0～14.9岁7个年龄段差异均有统计学意义,北京均高于广州.结论 北京、广州地区汉族男性儿童青少年部分年龄段骨龄高于实际年龄,且两地区骨龄在不同年龄段存在差异.本研究结论可为多中心骨龄地域差异研究、建立骨龄数据库及适时的骨龄评估标准提供一定参考.

Objective To study the difference of Han male children and adolescent bone age of wrist-hand in Beijing and Guangzhou.Methods Bone age （BA） of left hand-wrist was assessed using X-ray by two radiologists based on CHN atlas method in 993 healthy children and adolescents （age range：1.0-19.0 years）.The radiologists were blinded to the chronological age （CA） of those children.The interobserver variations were analyzed for evaluating the reliability of CHN Atlas method.The difference between CA and BA were separately assessed,and were analyzed by t test.Results Close correlation was found between BA and CA （r =0.969,0.957,P 〈 0.01） in both two regions.The bone age was advanced at 1.0-3.9,and 7.0-15.9 years in Beijing boys,and at 1.0-2.9,6.0-7.9 years in Guangzhou bpys.There was significant difference at 1.0-1.9,9.0-14.9 years between Beijing and Guangzhou.Conclusions The bone age of Han male children adolescent in Beijing and Guangzhou area has the characteristic of acceleration.There is significance difference at some years between Beijing and Guangzhou,and the results can provide potential value for the further study of BA and clinical medicine.