低浓度他克莫司液治疗慢性糜烂型口腔扁平苔藓的疗效观察

Treatment of Chronic Erosive Oral Lichen Planus with Low Concentrations of Tacrolimus

目的:本研究观察了0.015g/L的他克莫司液治疗糜烂型口腔扁平苔藓(oral lichen planus,OLP)的疗效。方法:选择2010年起在我科门诊就诊的患者60例随机分成两组,试验组30例采用0.015g/L的他克莫司液治疗,对照组30例采用康复新液治疗,疗程6个月,随访观察治疗6个月后显效率、不良反应和停药6月后复发率。结果:在6个月的治疗中,他克莫司液的治疗显效率、总有效率显著高于康复新液,两组差异有统计学意义(P<0.05)。2组显效患者随访停药后6个月内复发率比较,康复新液显著高于他克莫司液,两组差异有统计学意义(P<0.05),但在不良反应方面,两组发生率差异没有统计学意义。结论:0.015g/L的他克莫司液治疗慢性糜烂型口腔扁平苔藓具有良好的临床疗效。

To evaluate the efficacy of low concentrations of tacrolimus in the treatment of chronic ero sive oral lichen planus（OLP）. Methods： 60 patients in our department were divided into two groups （group A and B）. Group A was treated with 0. 015mg/mL concentrations of tacrolimus and group B was treated wlth Kangfuxin solution, the time was 6 months in a randomized clinical trial. We observe the effective rate and side effect occur rence in 6 months, and relapse rate within six months after treatment. Results： After treatment of 6 months, in the group A and B, the efficacy rate was 92.8% and 64%, respectively, and the relapse rate within 6 months after treatment was 15.8% and 66.7% respectively, there were significant differences between two groups （P〈0.05）, but there was no significant difference between two groups on the side-effect occurrence during the therapy. Con clusion： The results of the present work demonstrate that 0 . 015mg/mL concentrations of tacrolimus ig an effective therapy for chronic erosive oral lichen planus.