血清降钙素原(PCT)动态监测在儿童颅内感染中的应用研究

The clinical research of dynamic monitoring of procalcitonin (PCT) in children with intracranial infection

目的探讨血清降钙素原动态监测在儿童颅内感染中的应用价值。方法回顾性分析儿童中枢神经系统感染患儿56例,根据感染病原体分为病毒性脑膜炎(32例)和化脓性脑膜炎(26例),动态检测并比较两组患儿血清PCT值。结果治疗早期化脓性脑膜炎组的PCT动态监测水平显著高于病毒性脑膜炎组(P<0.05),治疗后期两组无显著性差异(P>0.05)。结论血清降钙素原动态监测对区分儿童化脓性脑膜炎和病毒性脑膜炎具有重要临床价值。

Objective To investigate the clinical value of dynamic monitoring of procalcitonin（PCT） in children with central nervous system infection. Methods A retrospective analysis of 56 children with intracra- nial infection was reviewed. According to the pathogens of infection, 32 children were enrolled in viral meningi- tis group and 26 patients in purulent meningitis group. The serum PCT level of two groups was dynamic moni- tored and compared. Results In early treatment, the PCT level in purulent meningitis group was significantly higher than that in bacterial meningitis group,there was statistical difference between two groups（P〈0. 05）. But in the late treatment two groups had no significant difference. Conclusions The dynamic monitoring of PCT has an important clinical value on distinguish purulent meningitis and viral meningitis in children.