哈萨克族、汉族冠心病患者血浆内脏脂肪素与冠状动脉粥样硬化程度的相关性

Correlation Between Plasma Visfatin and Coronary Atherosclerosis in Xinjiang Ka-zak and Han Patients

目的探讨新疆哈萨克族和汉族冠心病患者血浆内脏脂肪素水平与冠状动脉粥样硬化病变程度的相关性。方法选择哈萨克族冠心病患者40例及汉族患者45例，年龄在40—75周岁，均接受冠状动脉造影检查，并采用Gensini积分系统评估冠状动脉粥样硬化严重程度，将冠心病患者分为轻度和重度冠状动脉粥样硬化二个亚组，以40名汉族、35名哈萨克族健康人群作为对照组，采用双抗体夹心酶联免疫吸附法检测各组血浆内脏脂肪素水平，并检测肝、肾功能，血脂、血糖等。结果与对照组比较，哈萨克族与汉族冠状动脉粥样硬化组血浆内脏脂肪素水平显著升高（P〈0．01），两民族中重度冠状动脉粥样硬化组血浆内脏脂肪素水平均高于轻度冠状动脉粥样硬化纽，血浆内脏脂肪素水平与冠状动脉病变Gensini积分呈正相关（哈萨克族r=0．925，P〈0．01；汉族r=0．967，P〈0．01）。结论哈萨克族及汉族冠心病患者血浆内脏脂肪素水均高于各自对照组；两民族血浆内脏脂肪素水平与冠状动脉粥样硬化严重程度相关，提示内脏脂肪素可能参与了冠状动脉粥样硬化的发生及发展。

Aim To expore the correlation between plasma visfatin and coronary atherosclerosis in Kazak and Han patients with coronary heart disease. Methods Forty Kazak and forty-five Han patients with coronary heart dis- ease were picked out randmly as test groups aging from forty to seventy-five, then both test groups were divided into two subgroups （mild sub-group and heavy subgroup） using Gensini score respectively. Thirty-five Kazak and forty Han healthy people were picked out as control groups. Plasma visfatin was measured using enzyme-linked immunosorbent assay （ ELISA）, meanwhile liver function, renal function, blood lipids, blood glucose and fructosamine were measured. Re- suits Kazak and Hart patients with coronary heart disease had higher levels of plasma visfatin than control groups （P 〈 0. 01 ） ; the heavy subgroup had higher levels of plasma visfatin than the mild subgroup in Kazak and Han patients with cor- onary heart disease; there was a positive correlation between the level of plasma visfatin and Gensini score in the two na- tionalities （ r = 0. 925 and P 〈 0.01 for Kazak ; r = 0. 967 and P 〈 0.01 for Han）. Conclusions Kazak and Hart pa- tients with coronary heart disease had higher levels of visfatin than their control group. There was a positive correlation be- tween the level of plasma visfatin and Gensini score in the two nationalities, indicating that visfatin might be involved in the occurrence and development of coronary atherosclerosis.