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1-磷酸鞘氨醇受体在心血管系统中的作用及机制 被引量：3

Effects and Mechanisms of Sphingosine-1-Phosphate Receptors in Cardiovascular System
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摘要 1-磷酸鞘氨醇受体是1-磷酸鞘氨醇发挥细胞内作用的重要中转站,它包括5种亚型,广泛存在于包括心血管系统在内的各系统,在心血管系统发育、血管生成、血管舒张、血管屏障完整性、缺血/再灌注损伤和动脉粥样硬化等过程中具有重要的生物学作用。文章就1-磷酸鞘氨醇受体在心血管系统中的作用及其机制做一综述。 Sphingosine-l-phosphate receptors （S1PR） are important transit point for sphingosine-l-phosphate （S1P） to play roles in ceils. Five subtypes of S1PR have been identified so far, which are widely expressed in all systems including cardiovascular system, and play various important biological effects in cardiovascular development, angiogenesis, vasorelaxation, vascular barrier integrity, ischemia/ reperfusion injury and atherosclerosis. This paper makes a review on roles and mechanisms of S1PR in cardiovascular system.
作者 张大棣 张智超 伍荣 鲁艳菊 易光辉
机构地区 南华大学心血管病研究所动脉硬化学湖南省重点实验室 岳阳市第一人民医院
出处 《中国动脉硬化杂志》 CAS CSCD 北大核心 2013年第11期1047-1052,共6页 Chinese Journal of Arteriosclerosis
基金 国家自然科学基金项目(81270360) 湖南省科技厅科技项目(2012FJ4295)
关键词 1-磷酸鞘氨醇 G蛋白偶联受体 动脉粥样硬化 心血管系统 Sphingosine-l-Phosphate G Protein-Coupled Receptor Atherosclerosis Cardiovascular System
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献37

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二级参考文献91

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共引文献14

同被引文献23

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引证文献3

二级引证文献4

中国动脉硬化杂志
2013年 第11期

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