心外膜脂肪因子促进血管新生的分子机制

The Molecular Mechanism of Epicardial Adipokines Promoting Angiogenesis

心外膜脂肪组织是沉积在心脏尤其是冠状动脉周围的脂肪组织,可以表达多种脂肪因子参与动脉粥样硬化的发生与发展,最近这些脂肪因子已经被证实还可以引起冠状动脉粥样硬化斑块内的血管新生。这些新生血管在斑块内可能具有双重效应:一方面,新生血管具有很强的通透性,可以改善斑块局部缺氧状况;另一方面,新生血管可能促进斑块进展并导致其不稳定性增加。因此,通过研究脂肪因子致血管新生作用的机制,抑制斑块内的血管新生增强其稳定性可能成为未来治疗冠心病新的靶点。

Epicardial adipose tissue is a part of visceral tissue deposited around the heart, especially around coro- nary arteries, which can express many kinds of adipokines participating in the occurrence and development of atherosclero- sis. Recently it has been confirmed these adipokine can also cause angiogenesis within the coronary atherosclerotic plaque. These neovessels have very strong permeability, which can improve the condition of local hypoxia; new blood vessels, on the other hand, may promote the plaque＇ s progression and lead to its probability of instability increase. Thus, by studying the molecular mechanism of adipokines promoting angiogenesis, the inhibition of angiogenesis in the plaque to enhance the stability of the plaque can become a new target for therapy of coronary heart disease in the future.