5-羟色胺再摄取抑制剂联合极化液治疗老年抑郁症患者的疗效及安全性

Efficacy of selective serotonin reuptake inhibitors combined with polarized liquid in the treatment of se-nile depressive disorder

目的:评价5-羟色胺再摄取抑制剂(SSRIs)联合极化液对老年抑郁症的疗效及安全性。方法:69例符合国际疾病分类第10版抑郁发作诊断标准、年龄≥65岁的老年患者随机分为单用药组(单用SSRIs治疗)35例和合用药组(SSRIs+极化液治疗)34例。疗程均为4周。采用汉密尔顿抑郁量表(HAMD-17),汉密尔顿焦虑量表(HAMA)和临床大体印象量表(CGI)评估疗效,治疗中出现的症状量表(TESS)评估不良事件。结果:治疗4周,以合用药组HAMA总分、HAMD总分显著下降低于单用药组(F=17.28,F=10.24;P均<0.05)。合用药组CGI严重程度评分平均(1.5±0.4)分、TESS总分平均(9.4±1.2)分均显著低于单用药组(2.3±0.1)分和(10.5±3.5)分,差异有统计学意义(P均<0.05)。结论:SSRIs联合极化液治疗老年抑郁症较单用SSRIs的疗效好,安全性高。

Objective： To evaluate the efficacy and safety of selective serotonin reuptaker inhibitors （SS- Rls ） combined with polarized liquid in the treatment of senile depressive disorder. Method ：69 senile patients, who were 65 or over and met the criteria for depressive disorder based on international classification of diseases, 10th revision, were randomly divided into a single group （n = 35, single SSRIs） and a condaination group （n = 34, SSRIs ＋ polarized liquid） for 4 weeks. The treatment effectiveness was assessed by the Hamilton depression scale （HAMD） ,Hamilton anxiety scale（HAMA） ,and clinical global impression scale（CGI） while the adverse events were assessed by treatment emergent symptom scale （TESS）. Results：The HAMD and HAMA scores of the combination group were lowered more significantly than those in the single group at the end of the 4th week ,which showed significantly different （ F = 17. 28, F = 10. 24 ; all P 〈 0. 05 ）. CGI （ 1.5 ± 0. 4 ） score and TESS （9.4 ± 1.2） score of the combination group were also lowered more significantly than （2.3 ± 0. 1 ） score and （10.5 ±3.5）score of the single group,which showed significantly different （all P〈0.05）. Conclusion：SSRIs combined with polarized liquid in the treatment of senile depressive disorder have better efficacy and higher safety than the single SSRIs.